The INCITE project aims to demonstrate novel integrated upstream and downstream processing paths involving flow chemistry and membrane technology in chemo-enzymatic processes.  

 The modularity and flexibility of the developed processes will be showcased through 2 demonstration cases in real industrial settings. Such demonstrators will be using hydrolases for the sustainable, safe and energy-efficient production of commodity and fine chiral chemicals.

The first demonstration case– the “Oleochemical Track” relates to solvent-free synthesis of natural oleochemical esters using lipase enzymes finding applications in food/feed, personal care and crop protection. The second demonstration case – the “Agrochemical Track” – involves esterase-catalyzed production of a chiral molecule used as starting material with applications in crop protection and public health.

“Compared to traditional chemical synthesis processes, these chemo-enzymatic processes have clear advantages of greater efficiency, higher product quality and smaller environmental impact”
– Dirk Packet, Research Director, Oleon N.V.

“The development from TLR4-5 to TLR7 of the current key enabling technologies will open-up the way to their industrialization and thus lead to major positive economic and environmental impacts.”
– Carla Marchioro, R&D Director, ENDURA S.P.A

Key figures


52 months

from September 2019 to December 2023


European Union’s Horizon 2020 Research and Innovation Programme contribution:
€ 13.3 M

Total cost:
€ 17.4 M

7 partners

2 large/medium industries


2 Research and Technology Organisations


1 academic institution

1 innovation cluster

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